SIRT1 and non-small cell lung carcinoma: For example, in cells of non-small cell lung carcinoma, the S-nitrosylation of human Prx2 at Cys51 and Cys172 caused by GSNO disrupted the formation of the Prx2 dimer and suppressed its antioxidant activity, causing the accumulation of endogenous H2O2 and the activation of AMP-activated protein kinase (AMPK), which then activated sirtuin 1 (SIRT1).