The GRIM19-Tg HFD mice gained less body weight, as shown in Figure 3E, and had lower levels of metabolic indicators of obesity (e.g., serum glucose, aspartate aminotransferase, and alanine aminotransferase) compared to HFD-fed WT (WT HFD) mice, as shown in Figure 3F. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.