Using synthetical designed stapled peptides that stabilize and constrain an α-helical structure through N-methylation and macrocyclic ring formation, we have previously shown that disrupting the interactions between WASF3 and CYFIP1 effectively suppresses WASF3 activation and the invasion potential of breast and prostate cancer cells (Figure 3) [45]. The gene discussed is WASF3; the disease is Familial prostate cancer.