Aside, it has recently been reported that WASF3 phosphorylation acts to modulate a positive feedback loop between WASF3 and the PI3K-TGF-β-EGF signaling pathways [16], which supports previous findings that depletion of WASF3 expression in breast cancer cells prevents TGF-β-mediated EMT and lamellipodia formation in metastatic cells [30]. Here, TGFB1 is linked to breast cancer.