Interestingly, several drugs currently in use to control glycemia, such as SGLT-2 inhibitors and Glucagon-like peptide-1 (GLP-1), can also improve cardiac health due to their ability to act on different processes within the cell (endothelial dysfunction, inflammation, Ca2+ overload, mitochondrial dysfunction) [115,116,117]. This evidence concerns the gene GCG and endothelial dysfunction.