Several pharmacologic approaches are currently in use for the management of diabetes, including insulin injections, metformin, Sulfonylureas, peroxisome proliferator-activated receptor γ activators, Dipeptidyl peptidase-4 (DPP4) inhibitors, Glucagon-like peptide 1 (GLP-1) analogues, and Sodium–glucose co-transporter-2 (SGLT2) inhibitors [55]. This evidence concerns the gene INS and diabetes mellitus.