When this approach is made on post-mortem brain tissue from patients with schizophrenia, the canonical Gαq/11-protein pathway of 5-HT2ARs is found to be unaltered in the PFC, whereas the pro-hallucinogenic Gαi1-protein pathway is functionally overactive in the PFC [40,41]. The gene discussed is GNAQ; the disease is schizophrenia.