SF3B1 and myelodysplastic syndrome: The majority of MDS patients present anemia, which is often macrocytic and is usually caused by ineffective erythropoiesis, which is particularly accentuated in a subgroup of MDS, called MDS with ring sideroblasts (MDS-RS) according to the 2016 World Health Organization (WHO) classification [10], which are characterized by the presence of iron deposition in the mitochondria in the form of mitochondrial ferritin and by the somatic mutation of SF3B1, a gene encoding splicing factor [11,12].