PCYT1A and diffuse large B-cell lymphoma: In DLBCL cells, berberine promoted mitophagy-dependent necroptosis by inducing the formation of the RIP1/RIP3/MLKL necrosome complex and mRNA degradation of PCYT1A (phosphate cytidylyltransferase 1 alpha), thus reducing its expression in cancer cells [119] (Table 2).