In neuroblastoma cells, WA promoted ferroptosis through a dual mechanism: at high dose (10 μM), WA directly binds and inactivates GPX4, thus inducing canonical ferroptosis; at lower dose (1 μM), WA targets Keap1 and activates the Nrf2 pathway, leading to an excessive upregulation of HO-1 and a subsequent LIP increase [54] (Table 1). The gene discussed is NFE2L2; the disease is neuroblastoma.