In female nude mice (authors did not state the species) [135], and BALB/c nude mouse xenograft models of human nasopharyngeal [135,144], or lung cancer [136], shikonin reduced tumor growth and increased tumor cell necrosis [135,136,144], which, in the latter model, have been associated with an increase in RIP1 expression in the tumor tissue [136] (Table S4). Here, RIPK1 is linked to neoplasm.