IL6 and periodontitis: In lipopolysaccharide-stimulated normal human gingival fibroblast, cranberry non-dialyzable material (NDM) rich in proanthocyanidins decreased level of IL-6, what is consistent with other studies, but NDM significantly increased IL-6 in lipopolysaccharide-stimulated human gingival fibroblast cells from a patient suffering from aggressive form periodontitis (AgP fibroblasts) [28].