SAV1 and neoplasm: In the same year, the group of Wu et al. characterized the Ste-20 family Ser/Thr kinase Hippo (Hpo) and described a tumor-suppression pathway in which a kinase cascade consisting of Hpo, Salvador (Sav, an adaptor protein for Hpo) and Wts regulates cell proliferation and apoptosis by upregulating the transcription of the cell cycle regulators Diap1 and CycE10 [5].