However, progression to high-grade lesions and further to cancer is not predetermined by CD4+ depletion, i.e., is not a straightforward outcome of HIV-1-induced immune suppression [58,59], but rather an outcome of the accumulated changes in the host cell genome and transcriptome involving tumor suppressor genes, apoptosis-related genes, DNA damage-repair genes, and cell cycle regulatory genes [58,60,61]. This evidence concerns the gene CD4 and cancer.