LAMP2 and familial dilated cardiomyopathy: LAMP2 mutations cause Danon disease, a form of cardiomyopathy and skeletal myopathy, through impairment of macroautophagy [22], while DMD mutations cause muscular dystrophy and/or DCM through the loss of the stabilising protein dystrophin, leaving myocytes vulnerable to oxidative stress and calcium overload [23].