In a small population of children with AML (n = 7) and ALL (n = 10) who underwent induction therapy, Berger-Achituv and Elhasid have shown that neutrophils isolated from AML patients are characterized by decreased neutrophil elastase (NE) activity and low ability to form NETs after ex vivo stimulation with PMA [28]. This evidence concerns the gene ELANE and acute lymphoblastic leukemia.