PRRT2 and acute lymphoblastic leukemia: Indeed, in our material, PMA, an activator of protein kinase C (PKC) that triggers NETs release in a reactive oxygen species (ROS)-dependent manner [5,32], was unable to induce NETs formation in neutrophils isolated from ALL and AML patients before the initiation of antileukemic treatment (Figure 1) and in most of the patients after the first induction therapy (Figure 3A).