Regardless of the inducer used (phorbol myristate acetate, PMA, calcium ionophore, CI or N-formylmethionyl-leucyl-phenylalanine, fMLP), NETs release was significantly impaired in all acute leukemia diagnostic samples in comparison to healthy controls, as measured with quantitative NETs release assay (Figure 1, p < 0.0001, p = 0.0002, and p = 0.045 for PMA, fMLP, and CI, respectively) and observed in fluorescent microscopy (Figure 2). The gene discussed is FPR1; the disease is acute leukemia.