APOE and type 2 diabetes mellitus: As such, previous studies have showed that empagliflozin did not affect significantly the body weight of Zucker diabetic fatty (ZDF) rats (a type 2 diabetes animal model) at doses of 10 and 30 mg/kg/day, whereas it can decrease the body weight in ApoE(-/-) mice at a dose of 1–3 mg/kg/day for eight weeks [32,33].