SCD and Hypocholesterolemia: Lee et al. showed that selective deletion of Xbp1 in the liver led to decreased hepatic production of lipids through down regulation of critical lipogenic genes, such as Scd-1, diacyl glycerol acetyltransferase 2 (Dgat2) and acetyl coA carboxylase 2 (Acc2), and subsequently to marked hypocholesterolemia and hypotriglyceridemia [43].