IL1B and melanoma: As compared with parental cells, both vemurafenib-resistant cell clones showed in-creased secretion of IL-10, considered an important autocrine growth factor for malignant melanoma [32] and found to be upregulated in vemurafenib-resistant cells [33] of VEGF, a potent angiogenic factor also involved in BRAFi-resistance of melanoma cells [34], and of IL-1β and IL-8, cytokines that promote inflammation, tumorigenesis, and invasiveness [35].