Because Perilipin-1 is actively involved in lipolysis and PPARα in fatty acid oxidation, these findings are consistent with the observation of enhanced insulin sensitivity in the CD24 KO obesity model: insulin suppresses adipocyte lipolysis, such that fat cell lipolytic cascades are relatively inhibited, thus requiring lesser expression in proteins comprising the lipolysis machinery. Here, PPARA is linked to obesity due to melanocortin 4 receptor deficiency.