In addition, ligands of peroxisome proliferator-activated receptors (PPARs) are used as oral antidiabetics (PPARγ agonists: thiazolidinediones, TZDs), or for the treatment of dyslipidemia and cardiovascular diseases, due to their lipid-lowering properties (PPARα agonists: fibrates), as PPARs control transcription of a set of genes involved in the regulation of lipid and carbohydrate metabolism. This evidence concerns the gene PPARG and metabolic syndrome.