PLIN1 and obesity due to melanocortin 4 receptor deficiency: Because Perilipin-1 is actively involved in lipolysis and PPARα in fatty acid oxidation, these findings are consistent with the observation of enhanced insulin sensitivity in the CD24 KO obesity model: insulin suppresses adipocyte lipolysis, such that fat cell lipolytic cascades are relatively inhibited, thus requiring lesser expression in proteins comprising the lipolysis machinery.