Additionally, cytokines (such as IL-1, IL-2, IL-6, IL-8, IL-12, IL-18, INF-α, INF-β, INF-γ, and tumor necrosis factor [TNF]-α), growth factors (such as granulocyte-macrophage colony stimulating factor [GM-CSF]), cytolytic proteins (such as perforin), and serine proteases (such as granzyme B) constitute possible targets for anti-cancer immune modulation [92]. The gene discussed is TNF; the disease is cancer.