SET-NUP214 (9q34.11) was identified as a novel recurrent fusion gene in T cell leukaemia by Van Vlierberghe at al. They showed that SET-NUP214 may contribute to T-ALL pathogenesis by inhibition of T cell maturation through the transcriptional activation of HOXA genes, often predicting a poor outcome for patients [95]. Here, NUP214 is linked to acute lymphoblastic leukemia.