Besides intestinal anti-inflammatory activity related to antioxidant properties counteracting GSH depletion, inhibiting MPO activity and lipid peroxidation [50], the effects of 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin) in acute and subchronic phases of TNBS-induced intestinal inflammation was evaluated in comparison with effects of sulphasalazine and prednisolone in rats as well as in RAW264.7, Caco-2 and splenocytes culture cells [53]. Here, MPO is linked to gastroenteritis.