Clinical and experimental studies have shown that the benefits of PA in subjects with T1D are mainly related to the (1) increased insulin sensitivity in skeletal muscle, (2) possible positive effects on glycaemic control, (3) increased antioxidant defences and reduced oxidation, (4) decreased blood pressure, (5) reduction of cardiovascular diseases, (6) optimization of lipid profile and (7) enhancement of renal function [30]. This evidence concerns the gene INS and cardiovascular disorder.