Indeed, it has positive effects on (1) reduction of body weight and body mass index (BMI), (2) improvement in glucose tolerance and insulin sensitivity, (3) reduction of HbA1c level, (4) improvement of cardiorespiratory system, (5) reduction of cardiovascular disease risk (CVD) and (6) reduction of incidence of new cases of diabetes [17,49]. This evidence concerns the gene INS and cardiovascular disorder.