Adiponectin, leptin, and resistin are proteins (adipokines) that are synthesized and released from adipose tissue, with small amounts being produced in muscle [14,18] Often measured in obesity studies, these three cytokines have been linked to body fat content, inflammation, increased resting, and exercise-induced peripheral resistance as well as increased blood pressure. The gene discussed is RETN; the disease is obesity due to melanocortin 4 receptor deficiency.