Cycling more frequently and for a longer duration during a 12-week period, for 60 min five days per week at 65% VO2max, did not yield changes to FI or the homeostatic model assessment of insulin resistance (HOMA-IR), but did result in improvement in insulin sensitivity (IS) and the glucose infusion rate (GIR) during a hyperinsulinemic-euglycemic clamp, as well as a decrease in insulin C-peptide [87]. The gene discussed is INS; the disease is Insulin resistance.