Administration of total polysaccharides extracted from Pleurotus ostreatus in a high fat diet and STZ-induced type 2 diabetic rats for four weeks reduced hyperglycemia improved insulin resistance and increased glycogen storage by activating GSK-3 phosphorylation in liver and GLUT4 translocation in muscular tissue [71]. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.