Randomized controlled trials aimed to determine the oral hypoglycaemic effect of suspensions of freeze dried and powdered Pleurotus ostreatus and Pleurotus cystidiosus showed a significant reduction in fasting and postprandial serum glucose levels of healthy volunteers and reduced the postprandial serum glucose levels and increased the serum insulin levels of type 2 diabetic patients [97]. Here, INS is linked to type 2 diabetes mellitus.