From the other hand, the transcriptional variants COX1.3 (NM_001271165.1), COX1.4 (NM_001271368.1) and COX1.5 (NM_001271166.1) of the PTGS1 gene and the transcript COX2.1 (NM_000963.3) of the PTGS2 gene were observed in CRSwNP patients with milder course of CRSwNP. This evidence concerns the gene COX15 and chronic rhinosinusitis with nasal polyps.