The detailed analysis showed that in the case of PTGS1 gene, the replacement of COX1.3 (NM_001271165.1), which had typically the highest expression in healthy people, with COX1.1 (NM_000962) and COX1.2 (NM_080591) transcripts with a slight decrease of COX1.4 isoform (NM_001271368.1) in patients with CRSwNP was observed. Here, PTGS1 is linked to chronic rhinosinusitis with nasal polyps.