PTGS1 and type 2 diabetes mellitus: Similarly, the expression of mRNAs encoding cyclooxygenase 1 and 2 (Ptgs1 and Ptgs2, respectively), catalyzing the rate limiting step in PGE2 synthesis, was also significantly upregulated in islets from T2D mice compared to WT (with the latter also being higher in NGOB) (Figure 7D, middle).