CRC may exert its multiple effects via epigenetic regulation, of which the major targets include Nrf2, β-catenin, NF-κB, p38 MAPK, cyclooxygenase-2, forkhead box O3, inducible nitric oxide synthase, ROS, cyclin D1, VEGF, glutathione, TNF-α, and extracellular-regulated protein kinase. The gene discussed is NFKB1; the disease is colorectal carcinoma.