CCND1 and colorectal carcinoma: In 3T3-L1 cells, Ahn et al. [101] showed that CRC decreased aP2 (a mature adipocyte marker) mRNA expression, increased c-Myc and cyclin D1 expression (well-known Wnt targets), and inhibited mitogen-activated protein kinase (MAPK) phosphorylation, which has been associated with 3T3-L1 differentiation into adipocytes.