GFER and neoplasm: The Hippo signaling pathway was first discovered and determined as a key regulator of organ size in Drosophila melanogaster, following the identification of four tumor suppressors, Warts (Wts [2,3]), Salvador (Sav [4,5]), Hippo (Hpo [6,7,8,9,10]) and Mob-as-tumor-suppressor (Mats [11]).