MSLN and familial pancreatic carcinoma: In pancreatic cancer, the disruption of YAP transcriptional activity by Super-TDU suppresses secreted YAP/TEAD target genes implicated in extracellular matrix remodeling, such as AREG, CTGF, CYR61, fibroblast growth factor 1 (FGF1) and mesothelin (MSLN) [164].