Overexpression of CTGF and Cyr61 renders resistance to paclitaxel-induced apoptosis through upregulating B-cell lymphoma-extra large (Bcl-xL, encoded by the BCL2L1 gene), cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP) (they are anti-apoptotic proteins and function to inhibit the cell death induced by anti-cancer drugs), following the activation of the integrin αvβ3-ERK1/2 MAPK pathway or integrin-NF-κB pathway [97,98,99]. Here, BCL2L1 is linked to cancer.