Spatial proteomic analysis of TNBC via MIBI indicated that p53-positive tumor cells were mostly localized near immune cells in a subset of patients with tumor cells at the border of the stromal and tumor cell compartments were more transcriptionally active (identified by a different methylation pattern) compared to (non-necrotic) the tumor cells located in the core [24]. The gene discussed is TP53; the disease is neoplasm.