Based on IMC analysis, breast tumor cells of all subtypes that expressed carbonic anhydrase IX, a marker of hypoxia, were found to be associated with genomic gains of PD-L1, and heterozygous deletions of β2-microglobulin, suggesting that tumor cell hypoxia is associated with genomic alterations that facilitate immune evasion and suppression [39]. The gene discussed is CD274; the disease is breast neoplasm.