Analyses of prostatic tissue showed that the expression of insulin-like growth factor (IGF)-1 and IGF-2 in EGCG-treated HDF-BPH rats were significantly lower than those in untreated rats, and conversely, the tissue levels of IGF-binding protein-3 (IGFBP-3), peroxisome proliferator-activated receptor (PPAR)-α, and PPAR-γ in HDF-BPH rats were increased by EGCG treatment [102]. This evidence concerns the gene IGFBP3 and benign prostatic hyperplasia.