SIGLEC1 and neoplasm: Targeting this particular macrophage subset with a monoclonal antibody against CD169 coupled to ovalbumin (OVA) in the presence of adjuvant generated strong cytotoxic T cell (CTL) responses, which were absent after macrophage depletion using clodronate liposomes [9,11], and delayed tumor growth in the B16-OVA melanoma mouse model [13].