Therapeutic targeting of RAGE was shown to exert multiple beneficial effects through a variety of mechanisms, including preventing the accumulation of myeloid-derived suppressor cells in tumor tissue [195], sensitizing PDAC cells to oxidative injury [196], diminishing autophagy and inflammation [197], regulating mitochondrial bioenergetics [198], and modulating the crosstalk between pro-survival pathways in PDAC cells [199]. This evidence concerns the gene AGER and neoplasm.