miR-204 is the most enriched miRNA in human β cells [68].Of note, this miRNA has been demonstrated to control the expression of MafA and of GLP1R. Xu et al. showed that miR-204 expression is regulated by thioredoxin-interacting protein (TXNIP), a cellular redox regulator involved in β cell physiology whose expression is increased in pancreatic islets in T2D. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.