Collectively, these results suggest that the observed reduction of miR-184-3p and the consequent upregulation of its target gene CRTC1 in pancreatic islets of T2D donors is subsequent to the reduction/translocation of NKX6.1 occurring in dedifferentiating and/or dysfunctional β-cells in T2D, thus representing a link between protection and dedifferentiation [77]. This evidence concerns the gene NKX6-1 and type 2 diabetes mellitus.