While no CHM constituents have been reported to exert a specific action on cytokine receptors, a CHM formula comprised of eight herbs for the treatment of postpartum depression, known as the Shen-Qi-Jie-Yu decoction (1.25 g/mL, 1, 2, 4 weeks, i.g.), has recently been shown to produce antidepressant effects by decreasing the expression of cytokine receptors, such as IL-1R1 and glycoprotein 130, in the hippocampus in a rat model of postpartum depression [54]. Here, IL1R1 is linked to postpartum depression.