CRC regulated molecules of the intrinsic apoptotic pathway (Bax, Bcl-2, caspase 3, and caspase 9), improved the glutathione system, and prevented iron deposition in the dopaminergic neurons, and formation of α-synuclein aggregates in the dopaminergic neurons, implying CRC’s beneficial effects on PD. Here, CASP3 is linked to colorectal carcinoma.