IL1A and colorectal carcinoma: CRC has potent anti-oxidant activity, which scavenges ROS, increases antioxidant levels, decreases lipid peroxidation, chelates toxic metals to reduce injury in AD brains [92,93,94] CRC was shown to downregulate the inflammatory cytokines, including IL1, IL6, TNF-α, interferon-γ, and cyclooxygenase (COX)-2 activity [95].