KRAS and colorectal carcinoma: For HT29 (CRC cell line that contains wild-type KRAS), RAW264.7 (mouse macrophage-like cells) and SW480 without treatment, more than 40% of the cells from these lines received significant levels of SW480 cells-derived exosomes (Figure 6c), but no significant change of cell viability was observed after the exosome uptake (Figure 7a,b,e).