Consistent with this previous finding, Western blot analysis in our study showed that FTS treatment increased p53 in SW480 cells, implying that KRAS inhibition by FTS may trigger stress in the colon cancer cells, and p53 as a stress sensor [19] could possibly mediate the secretion of more exosomes as a cellular response to the intervention. This evidence concerns the gene TP53 and malignant colon neoplasm.