After ruling out the possibility of UBR5 regulating E-cadherin through promoter hypermethylation, Liao et al. speculated that UBR5 ubiquitinates certain transcriptional repressors of E-cadherin and accordingly found that Snail1 and Twist levels were slightly elevated in tumor cells, although further study is needed to better delineate the molecular mechanism [41]. This evidence concerns the gene SNAI1 and neoplasm.