CD8+ T cells, CD4+ T helper 1 (Th1), M1 macrophages, NK cells and DC have anti-tumor effects, whereas Th2, Th17 and regulatory T cells (Tregs) exhibit both of these opposing effects in animal models and clinical trials; however, B lymphocytes, M2 macrophages, MDSC and mast cells usually have pro-tumor effects [16,17]. Here, CD4 is linked to neoplasm.