The shedding of Epithelial cell adhesion molecule positive EVs (EpCAM+ EVs) into the ascites of patients with ovarian carcinoma [6] has been shown previously, as well as the release of tissue-factor-positive EVs (TF+ EVs) from various ovarian carcinoma cell lines, especially those of the serous subtype [7]. This evidence concerns the gene F3 and ovarian carcinoma.