CD274 and neoplasm: The NCT02324257 study (CD3xCEA in combination with atezolizumab (anti-PD-L1) for patients with advanced CEA-positive tumors) has been completed and seemed to be in line with previous preclinical results: the combination of CD3-BsAbs with checkpoint blockade showed better anti-tumor responses when compared to CD3-BsAb monotherapy and they found no evidence of increased toxicities [72].