ESK1, an ImmTAC recognizing intracellular Wilms’ tumor 1 (WT1) antigen presented in HLA-A*02:01, was able to lyse WT1-positive tumor cells in vitro and reduce tumor outgrowth of AML, ALL and mesothelioma tumors in NSG mice [103]. The gene discussed is HLA-A; the disease is neoplasm.