HLA-DRB1 and allergic disease: Whereas DRB1 * 03: 01, and two similar in structure HLA-DRB1*14:19 and *14:21 but also DRB1 * 04: 04, DRB1 * 12: 01 and DRB1 * 15:01 have been considered as alleles of protection against allergy due to weak binding to allergens [12,21].