Transcriptome analysis also revealed TLR and PI3K/AKT signaling regulation by calcitriol; this is in line with our finding that calcitriol regulates MAPK and NF-κB cascades, since ERK is activated by TLR signaling [38], while pNF-κΒ is implicated in both PI3K/AKT and TLR signaling cascades [38,39], and both regulate important cellular processes concerning cancer cell proliferation and inflammation [40,41]. The gene discussed is NFKB1; the disease is cancer.