Finally, we evaluated by flow cytometry the protein expression of CYP24A1, a well-known target gene of the activated VDR, and found significantly lower percentages of CYP24A1+ cells in CLL cases versus healthy donors (FD: 1.4, p < 0.01) (Figure 1G). The gene discussed is CYP24A1; the disease is B-cell chronic lymphocytic leukemia.