T cell phenotypes within the tumor do not mirror the immune composition in peripheral blood [34], where T cells do not show such an exhausted phenotype, as exemplified by a study conducted in melanoma-patients where the ratio and absolute numbers of CD4+ and CD8+ T cells in peripheral blood were found comparable to age-matched healthy donors [35], as well as the frequencies of memory T cell subsets, which did not show increased expression of inhibitory receptors. This evidence concerns the gene CD8A and neoplasm.