Although this procedure is not selective for APP Tyr682 residue (APP has indeed other two Tyr(s) whose changes in the phosphorylation can also easily be detected by the same procedure), previous findings from our group proved that only APP Tyr682 residue phosphorylation is crucial in initiating APP amyloidogenic processes in AD neurons, whereas Tyr phosphorylation at different APP sites does not affect the extent of Aβ production or accumulation [8,9]. The gene discussed is APP; the disease is Alzheimer disease.