INS and Hypoglycemia: There are certain works that along with BG, insulin and CHO made use of additional data e.g., physical activity (PA) data and HR etc. Nocturnal hypoglycemia was predicted from BG, insulin, CHO and PA data by Calhoun et al. [45], Bertachi et al. [51], Bertachi et al. [41] and Güemes et al. [60].