KEAP1 and non-small cell lung carcinoma: For instance, a report by Anju Singh et al. (2016) evaluated and validated the selective and specific delivery of ML385, a specific Nrf2 inhibitor in combination with carboplatin, in NSCLC-A549 cells with Keap1 mutation, and this nanoformulation delivered effective preclinical results as a promising strategy to treat Nrf2-mediated NSCLC [157].