CUL3 and hepatocellular carcinoma: According to The Cancer Genome Atlas (TCGA) reports, the exclusive mutations were reported in the Nrf2, E3 ubiquitin ligase complex, Keap1, cullin3 (CUL3), and Cullin-associated NEDD8-dissociated protein 1 (CAND1) factors in hepatocellular carcinoma (HCC) [122,123].