NFE2L2 and neoplasm: Furthermore, Nrf2 could also promote the PPP gene (Serine/threonine phosphatase, PPP) expression in prostate and lung cancer cells due to a Keap1 loss-of-function mutation that fosters tumor growth and metastasis through the upregulation of G6PD, transketolase (TKT), and phosphogluconate dehydrogenase (PGD) and the epigenetic impairment of miR-1 and miR-206 [145].