Other Nrf2 targets involved in ROS-mediated oxidative stress are the redox cycling enzymes, viz., thioredoxin, glutathione peroxidase, superoxide dismutase 1, catalase, peroxiredoxin, sulfiredoxin etc., These cytoprotective proteins generated by Nrf2 protect a cell from various oxidative insults, including carcinogen-induced cancers [136]. Here, NFE2L2 is linked to cancer.