NFE2L2 and lung cancer: For instance, Nrf2 can confer the gene expression coding for NADPH-generating enzymes, viz., G6PD, PGD (phosphogluconate dehydrogenase), TKT (transketolase), and TALDO1 (transaldolase 1) in A549, H2126, and LK-2 lung cancer cells, and these genes are involved in cancer cell proliferation with a constitutive activation of PI3K/Akt signaling [132].