Serum calponin 3 levels in SSc patients (15.38 ng/mL; 95% confidence interval [CI], 14.66 to 16.11) were significantly higher than those in healthy controls (13.56 ng/mL; 95% CI, 12.75 to 14.38, p < 0.05; Figure 1). The gene discussed is CNN3; the disease is systemic sclerosis.