CNN3 and systemic sclerosis: For the SSc subgroups, serum calponin 3 levels in dcSSc patients (15.81 ng/mL; 95% CI, 14.66 to 16.97) were significantly increased compared to those in healthy controls (13.56 ng/mL; 95% CI, 12.75 to 14.38, p < 0.05), while there were no significant differences in the serum calponin 3 levels between lcSSc and healthy controls (p = 0.29).