A panel of HF features were improved as a consequence of XO inhibition: myocardial mechanical and energetic efficiency, LVEF, cardiac remodeling, endothelial dysfunction, peripheral tissue perfusion, coronary flow reserve, cachexia, and plasma brain natriuretic peptide (BNP) levels [73,76,123,124,125,126,127,128,129]. This evidence concerns the gene XDH and endothelial dysfunction.