The decrease of POU1F1 (POU Domain, Class 1, Transcription Factor 1; OMIM 173110) is implicated in growth retardation combined with pituitary hormone deficiency [20], reported in different patients affected by ZIKV, same as possible subtraction of ZNF214 (Zinc Finger Protein 214; OMIM 605015) involved in Beckwith-Wiedemann syndrome-BWSCR2 (Beckwith-Wiedemann Syndrome Chromosome Region-2) characterized by mild intellectual disability, obesity and characteristic dysmorphic features [21]. Here, POU1F1 is linked to obesity due to melanocortin 4 receptor deficiency.