INS and diabetes mellitus: In particular PDX1 (Pancreas/Duodenum Homeobox Protein 1; OMIM 600733) is associated with early-onset of insulin dependent diabetes mellitus [45]; NKX6-1 (NK6, Homolog of Drosophila 1O; OMIM 602563) is implicated in development of insulin producing beta cells in the islets of Langerhans [46]; and TCF7L2 (Transcription Factor 7-Like 2; OMIM 602228) is involved in blood glucose homeostasis [47].