In vivo, liver injured tissue promotes inflammatory processes that stimulate MSCs to release various growth factors and cytokines such as HGF, EGF, IL-6 and TNF-α [146], and among them, HGF plays a well-established role in liver pathogenesis by attenuating liver fibrosis in various in vivo models [147,148,149,150]. Here, HGF is linked to Hepatic fibrosis.