While AD is characterized by both the abnormal aggregation of hyperphosphorylated tau protein which gives rise to neurofibrillary tangles and amyloid β (Aβ) accumulation in extracellular plaques [1], neuroinflammation and oxidative stress are thought to be important contributors to AD pathology and neurodegeneration [2,3,4,5]. This evidence concerns the gene MAPT and Alzheimer disease.