Apparently contrasting with the latter, a study on a non-specific inhibitor of SOCE (SKF-96365) is related to a significant downturn in Homer 1 expression levels upon inhibitor application, whereby protective effects of SOCE inhibition on the same PD model system were posed to relate to a regulatory role of Homer in ER Ca2+ levels [90]. The gene discussed is HOMER1; the disease is Parkinson disease.