The modulation of SOCE by SARAF seems to comprise high clinical relevance, considering recent reports on altered transcript levels of SARAF in patients suffering from pancreatitis, as well as transient interactions between SARAF and STIM1 together with increases in Ca2+ entry in cells originating from mice with induced pancreatitis, implicating that restoration and/or stabilization of SARAF might pose promising treatment strategies [133]. This evidence concerns the gene SARAF and pancreatitis.