Somocystinamide A (Figure 31c), a lipopeptide isolated from L. majuscula, exhibits cytotoxicity on Jurkat (IC50 3nM) and CEM leukemia (IC50 14 nM), A549 lung carcinoma (IC50 46 nM), Molt4 T leukemia (IC50 60 nM), M21 melanoma (IC50 1.3 nM) and U266 myeloma (IC50 5.8 μM) cell lines by inducing apoptosis via caspase 8 [101] (Table 1). This evidence concerns the gene CASP8 and leukemia.